Dehalogenation of functionalized alkyl halides in water at room temperature
نویسندگان
چکیده
منابع مشابه
Dehalogenation of Functionalized Alkyl Halides in Water at Room Temperature.
Alkyl bromides and chlorides can be reduced to the corresponding hydrocarbons utilizing zinc in the presence of an amine additive. The process takes place in water at ambient temperatures, enabled by a commercially available designer surfactant. The reaction medium can be readily recycled, and the amount of organic solvent invested for product isolation is minimal, leading to very low E Factors.
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An operationally simple iron-catalyzed hydrodehalogenation of aryl halides has been developed with 1 mol% Fe(acac)(3) and commercial t-BuMgCl as reductant. The mild reaction conditions (THF, 0 degrees C, 1.5 h) effect rapid chemoselective dehalogenation of (hetero)aryl halides (I, Br, Cl) and tolerate F, Cl, OR, SR, CN, CO(2)R, and vinyl groups.
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ژورنال
عنوان ژورنال: Green Chemistry
سال: 2015
ISSN: 1463-9262,1463-9270
DOI: 10.1039/c4gc01733a